The vasoconstriction caused by a pyrogen*

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Synthesis of Endogenous Pyrogen by Rabbit Leukocytes

Rabbit ieukocytes from peritoneal exudates and from blood were stimulated to form leukocyte pyrogen in the presence of radiolabeled amino acids. The stimuli used were endotoxin, phagocytosis, and tuberculin. The crude leukocyte pyrogen samples were purified; pyrogen from exudate cells was rendered homogeneous; pyrogen from blood cells was still contaminated with other proteins. All the purified...

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Renal vasoconstriction caused by short-term cholesterol feeding is corrected by thromboxane antagonist or probucol.

Recent studies indicate that short-term cholesterol feeding causes vascular hyperreactivity and/or increased tone in certain vascular beds. The present study in rats examined the effect of 3 wk of cholesterol-supplemented diet (CSD) on renal hemodynamics. We tested the hypothesis that LDL oxidized in vivo is causally related to increased renal vascular tone by adding the antioxidant drug probuc...

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Endogenous Pyrogen

Abs t rac t -The effect of aging on the ability of macrophages to produce endogenous pyrogen/interleukin-1 (EP/IL-I) was tested in 13 young adult (2-3 mo) and 13 aged (24-26 mo) Fischer rats using a febrile response assay. Peritoneal macrophages from aged rats produced EP/IL-1 as well as young adult rats. Decreased production of EP/IL-1 does not appear to explain the diminished febrile response...

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ژورنال

عنوان ژورنال: The Journal of Physiology

سال: 1957

ISSN: 0022-3751

DOI: 10.1113/jphysiol.1957.sp005859